Drug Delivery

Hydralese®Rx

Solesis’ Research & Development team has developed HydraleseRx, a novel polymer platform for drug delivery systems that enables the controlled release of active pharmaceutical ingredients (APIs). HydraleseRx offers unparalleled advantages over traditional polymers currently used in drug delivery devices, empowering the creation of innovative, custom-engineered drug delivery solutions for complex, long-acting therapeutic applications.

Learn more about Solesis’ HydraleseRx drug delivery technology as we build better solutions, together.

The HydraleseRx Difference

Solesis’ patented HydraleseRx platform provides a library of bioresorbable and biocompatible elastomers composed of poly(glycerol ester) urethanes (PGEUs). These versatile polymers enable controlled-release from days to months, supporting a broad range of drug delivery systems.

Backed by decades of research, HydraleseRx boasts tunable properties that make it an ideal excipient for various administration routes, including implantable devices, injectable formulations, and oral or transdermal drug delivery systems.

This versatility supports multiple therapeutic areas, from women’s health to therapies targeting the sensory organs, central nervous system, and endocrine system.

Examples of applications include:

Subcutaneous implants, such as rods or closed geometries, for pain management, HIV prevention, contraceptives, and multipurpose prevention therapy (MPT)

Subcutaneous implants, such as rods or closed geometries, for pain management, HIV prevention, contraceptives, and multipurpose prevention therapy (MPT)

Microspheres and microparticles, such as multi-particulate medication delivery systems for parenteral or oral administration

Microparticles, multi-particulate medication delivery systems for parenteral or oral administration

Gastroretentive devices, such as torus rings, flat rings, and star-shaped geometries designed for controlled oral drug release

Gastroretentive devices, such as torus rings, flat rings, and star-shaped geometries designed for controlled oral delivery

As we collaborate to understand your goals and target product profile, our team uses digital twin modeling to fine-tune your HydraleseRx excipient, optimizing for API characteristics, therapeutic dose, degradation profile, and release kinetics.

HydraleseRx was developed to address key challenges therapy developers face during drug delivery device development, offering:

Molecule Types Biocompatible Biodegradable Linear Release Kinetics
Small molecule APIs Minimal pH change observed in vitro during HydraleseRx degradation Degradation timeframe of 3 to 12+ months; degrades into monomers metabolized by the body Near-zero-order release kinetics
Large molecule APIs No residual inflammation or fibrous encapsulation
Biologics All tissues return to normal upon degradation of HydraleseRx after subcutaneous implantation in rats

Small molecule APIs

Biocompatible
Minimal pH change observed in vitro during HydraleseRx degradation
Biodegradable
Degradation timeframe of 3 to 12+ months; degrades into monomers metabolized by the body
Linear Release Kinetics
Near-zero-order release kinetics

Large molecule APIs

Biocompatible
No residual inflammation or fibrous encapsulation

Biologics

Biocompatible
All tissues return to normal upon degradation of HydraleseRx after subcutaneous implantation in rats
Highly Flexible High Drug Loading Shelf Stable Variety of Manufacturing Processes
Flexible at high drug loadings; suitable for applicator use Enables high drug loading up to 60% w/w in solvent-free formulations Room-temperature and humidity shelf storage; compatible with terminal gamma sterilization; stable post-sterilization for up to 6 months
  • Extrusion
  • Molding
  • Casting
  • Coating
  • Emulsion
  • 3D Printing
  • Foaming

Flexible at high drug loadings; suitable for applicator use

High Drug Loading
Enables high drug loading up to 60% w/w in solvent-free formulations
Shelf Stable
Room-temperature and humidity shelf storage; compatible with terminal gamma sterilization; stable post-sterilization for up to 6 months
Variety of Manufacturing Processes
  • Extrusion
  • Molding
  • Casting
  • Coating
  • Emulsion
  • 3D Printing
  • Foaming

In Vitro Release of 2’-Deoxyadenosine with HydraleseRx

In Vitro Release Comparison of PLGA, PCL, & HydraleseRx
Leverage Our Polymer Development Expertise
From Concept to Patient

Whether you’re developing a new therapy or extending an existing one, our drug delivery excipient development and polymer synthesis capabilities enable you to create optimized formulations based on your target product profile.

Our team can develop, test, and characterize prototypes in-house, supporting your translational product development from early R&D to cGMP production.

We provide:

  • In-house analytical testing and method validation
  • ISO 7 and 8 cleanrooms
  • In vitro release and polymer degradation testing
  • Process development and optimization

We support your development through GLP and GMP phases, including:

  • Discovery & development
  • Preclinical research
  • Phase I/II clinical development
  • Technical transfer
  • Scale up

By leveraging the full potential of HydraleseRx, we help optimize your next breakthrough in drug delivery technology.

Explore Our Manufacturing Expertise
Learn More About HydraleseRx

Explore our articles, data sheets, and presentations for in-depth insights into HydraleseRx and our digital twin AI modeling, which enables efficient development of excipient and drug delivery systems.

View Resources
HydraleseRx Datasheet

Discover more about the HydraleseRx platform and how it can accelerate your drug delivery solutions.

View Data Sheet

Enabling Accelerated Development of Drug-Loaded Polyester-Based Implants Through Multiphysics Modeling (PODD 2025)

Learn how Solesis’ multiphysics digital twin modeling enables faster selection and optimization of HydraleseRx excipients based on your target product profile.

View Presentation

Let’s Push the Boundaries of Performance Materials—Together

At Solesis, we’re ready to partner with you—combining fresh thinking and proven expertise to help you create the next breakthrough in drug delivery devices.

Explore Partnership Options